Check Intently (3)pentobarbital will decrease the extent or influence of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Solid or reasonable CYP3A4 inducers may maximize fee of diazepam elimination; as a result, efficacy of diazepam might be lessened.pentobarbital will lower the extent or influence o